276°
Posted 20 hours ago

Siaki Collection 76725 Porcelain Dinnerware Set, White, 18 Pieces, Polyester

£9.9£99Clearance
ZTS2023's avatar
Shared by
ZTS2023
Joined in 2023
82
63

About this deal

Zaccone V, Falsetti L, Nitti C, Gentili T, Marchetti A, Piersantelli MN, et al. The Prognostic Role of Procalcitonin in Critically Ill Patients Admitted in a Medical Stepdown Unit: A Retrospective Cohort Study. Sci Rep. 2020; 10: 4531. pmid:32161314

Pattharanitima P, Vaid A, Jaladanki SK, Paranjpe I, O’Hagan R, Chauhan K, et al. Comparison of Approaches for Prediction of Renal Replacement Therapy-Free Survival in Patients with Acute Kidney Injury. Blood Purif. 2021; 50: 621–7. pmid:33631752 All patients were also classified into four groups to assess the effect of minimizing the fluid overload using CRRT on mortality: Group 1 (n = 182, %FOpreCRRT ≤ 4.6% and %FOtotal ≤ 9.6%; no significant fluid overload before and after CRRT application, and finally, no significant total fluid overload); Group 2 (n = 140, %FOpreCRRT > 4.6% and %FOtotal ≤ 9.6%; significant fluid overload before CRRT that was then resolved by CRRT, and finally, no significant total fluid overload); Group 3 (n = 103, %FOpreCRRT ≤ 4.6% and %FOtotal > 9.6%; no significant fluid overload before CRRT, but significant total fluid overload due to aggravation of fluid overload during CRRT); and Group 4 (n = 118, %FOpreCRRT > 4.6% and %FOtotal > 9.6%; significant fluid overload before CRRT, which was not resolved by CRRT, and finally, significant total fluid overload). In the present study, we demonstrated that both %FOpreCRRT and %FOtotal were independent risk factors for the 28-day mortality in patients with SIAKI receiving CRRT, and the results of our study are in line with those of previous studies. However, most previous studies have only assessed fluid accumulation either before RRT 10, 14, 15 or during the period of ICU or hospital stay 11, 12. In contrast, the present study assessed both %FOpreCRRT, in which initial fluid resuscitation was implemented in patients with SIAKI, and %FOtotal, in which the effect of CRRT on fluid overload was reflected. Thus, our study clarified the association between fluid overload and survival in these patients. Finally, the multivariable analysis of our study demonstrated that patients with %FOpreCRRT > 4.6% and %FOtotal > 9.6% were 1.9- and 3.37-times more likely to die within 28 days after ICU admission than those with %FOpreCRRT ≤ 4.6% and %FOtotal ≤ 9.6%. Furthermore, this association between survival and fluid overload was consistent across various subgroups, including the high SOFA group (> 14 points) or low SOFA group (≤ 14 points), late CRRT group (> 1.5 days) or early CRRT group (≤ 1.5 days), age > 65 or ≤ 65 years, male or female sex, diabetes or no diabetes, and oliguria or no oliguria, suggesting a robust effect of fluid overload on survival in patients with SIAKI receiving CRRT.

Kan WC, Huang YT, Wu VC, Shiao CC. Predictive Ability of Procalcitonin for Acute Kidney Injury: A Narrative Review Focusing on the Interference of Infection. Int J Mol Sci. 2021; 22. pmid:34199069

Oh, H. J. et al. Early initiation of continuous renal replacement therapy improves patient survival in severe progressive septic acute kidney injury. J. Crit. Care 27(6), 743–749 (2012). Hoste EA, Bagshaw SM, Bellomo R, Cely CM, Colman R, Cruz DN, et al. Epidemiology of acute kidney injury in critically ill patients: the multinational AKI-EPI study. Intensive Care Med. 2015; 41: 1411–23. pmid:26162677 CLP sepsis induces early acute kidney injury. (A) Scr had significant increases in CLP24hAKI ( n = 4) and CLP48hAKI ( n = 3) mice compared with CLPnoAKI( n = 3) mice (CLP24hAKI vs. SO, 0.19 ± 0.05 vs. 0.12 ± 0.06, p = 0.011; CLP48hAKI vs. SO, 0.21 ± 0.05 vs. 0.12 ± 0.06, p = 0.003). (B) Serum BUN had significant increases in CLPnoAKI compared with SO ( n = 3) and CLP48hAKI mice(CLPnoAKI vs. SO, 29.1 ± 9.3 vs. 18.9 ± 1.2, p = 0.039; CLPnoAKI vs. CLP48hAKI,29.1 ± 9.3 vs. 16.2 ± 7.8, p = 0.013); there are no differences among NC ( n = 3), SO, CLP24hAKI and CLP48hAKImice. NC, Normal control C57 mice; SO, Sham Operation; CLPnoAKI, CLP without AKI; CLP24hAKI, AKI after CLP 24 h; CLP48hAKIAKI after CLP 48 h. *, p<0.05; **, p<0.01; NS, p> 0.05.Oh, H. J. et al. Can early initiation of continuous renal replacement therapy improve patient survival with septic acute kidney injury when enrolled in early goal-directed therapy?. J. Crit. Care 35, 51–56 (2016). Mat Nor MB, Md Ralib A. Procalcitonin clearance for early prediction of survival in critically ill patients with severe sepsis. Crit Care Res Pract. 2014; 2014: 819034. pmid:24719759 Honore PM, Redant S, De Bels D. Reliability of biomarkers of sepsis during extracorporeal therapies: the clinician needs to know what is eliminated and what is not. Crit Care. 2020; 24: 553. pmid:32917263 Fig 3. Receiver-operating characteristic curves of % PCT decrease for predicting survival (A) and recovery from dialysis (B) within 28 days after CRRT initiation in patients with SIAKI receiving CRRT.

Continuous variables were expressed as medians with interquartile ranges and were compared using the Mann–Whitney test. Categorical variables were expressed as numbers with percentages and compared using the chi-square test. To determine the independent predictors for survival and recovery from dialysis within 28 days after CRRT initiation, univariable and multivariable Cox proportional hazards analyses were used, and the results were presented as hazard ratios (HR) and 95% confidence intervals (CIs). Significant variables were identified through univariable analysis ( P< 0.1), and clinically important variables were considered in the multivariable analysis. Of the significant variables in the univariable analysis, those included in the SOFA or APACHE II scores i.e., mean arterial pressure, platelet count, pH, and serum creatinine were excluded from the multivariable analysis to avoid a redundant analysis. Instead, the SOFA and APACHE II scores for these variables were considered in the final multivariable analysis. Barbar, S. D. et al. Timing of renal-replacement therapy in patients with acute kidney injury and sepsis. N. Engl. J. Med. 379(15), 1431–1442 (2018).The present study has several strengths. First, although the subjects of the present study were limited to patients with SIAKI receiving CRRT, it included a relatively large number of patients (n = 649) compared with previous studies that examined the prognostic value of PCT decrease in patients with sepsis (sample size, n = 27–242) [ 14]. Second, our multivariable model included adjustments for important confounding variables that are reported to impact survival and recovery from dialysis in patients with AKI receiving CRRT, such as oliguria, SOFA scores, APACHE II scores, and interval time from AKI diagnosis to CRRT initiation. All these findings provide more substantial evidence of the association between PCT and survival or recovery from dialysis at 28 days in patients with SIAKI receiving CRRT. Mehta, R. L. et al. Spectrum of acute renal failure in the intensive care unit: the PICARD experience. Kidney Int. 66(4), 1613–1621 (2004). Mandelbaum T, Scott DJ, Lee J, Mark RG, Malhotra A, Waikar SS, et al. Outcome of critically ill patients with acute kidney injury using the Acute Kidney Injury Network criteria. Crit Care Med. 2011; 39: 2659–64. pmid:21765352 Jhee, J. H. et al. Cumulative fluid balance and mortality in elderly patients with acute kidney injury requiring continuous renal-replacement therapy: A multicenter prospective cohort study. Kidney Res Clin Pract 39(4), 414–425 (2020). Jarvisalo MJ, Hellman T, Uusalo P. Mortality and associated risk factors in patients with blood culture positive sepsis and acute kidney injury requiring continuous renal replacement therapy-A retrospective study. PLoS One. 2021; 16: e0249561. pmid:33819306

Asda Great Deal

Free UK shipping. 15 day free returns.
Community Updates
*So you can easily identify outgoing links on our site, we've marked them with an "*" symbol. Links on our site are monetised, but this never affects which deals get posted. Find more info in our FAQs and About Us page.
New Comment