Denamarin for Medium Dogs Tablet 225 mg, Pack of 30 Tablets

Product Information

Denamarin chewable tablets containing SAMe (s-adenosylmethionine) and silybin can be used in dogs of all sizes to help support healthy liver functions. In addition, research has shown the administration of Denamarin chewable tablets to be safe for dogs. Denamarin Liver Health Supplements are brought to you by Nutramax Laboratories Veterinary Sciences, the #1 veterinarian recommended supplement company. *Source: Survey conducted among small animal veterinarians who recommended animal supplements. Key Benefits: S-Adenosylmethionine 172 mg and Silybin-phosphatidylcholine complex (SPC) 123 mg, providing 35 mg of Silybin A+B A stabilised form of the S,S-SAMe isomer, the predominant form synthesised in cells and the isomer which is biologically active In addition to supporting liver health, Denamarin may also support brain health as S-Adenosylmethionine has been shown to function as a neuroprotective agent. 4,18,19 Note: These are general guidelines. Always consult with a veterinarian for the correct dosage for your dog. Uses of Dexamethasone in Dogs

There are no known drug interactions or contraindications to the use of silybin/silymarin in animals. 33,34 While mild side effects, such as gastrointestinal upset, itching and headache, have been rarely reported in primates, 33,35,36 no side effects have been noted in dogs or cats. 13,16,33,34,37,38 The specific silybin-phosphatidylcholine complex in Denamarin has been evaluated in both acute and chronic use safety studies: an acute toxicity study in dogs using levels greater than 80x the amount in Denamarin revealed no adverse physiologic effects, 38 and a chronic toxicity study in monkeys who received greater than 80x the amount in Denamarin for 26 weeks showed no compound-related adverse effects. 35 Administration As A Liver Health Supplement nutramax LABORATORIES, VETERINARY SCIENCES, INC., 1550 Yorkton Ct, Unit 13, Burlington, ON L7P 5B7 Canada

The number of tablets administered may be gradually reduced, or increased, at any time at the recommendation of your veterinarian. Plasma levels in dogs after oral administration of silymarin versus SPC (silybin-phosphatidylcholine complex). Each was given at the same amount based on silybin content (178mg). 13 Safety The daily dose for dogs up to 6 lbs is 1/4 tablet. For dogs 7-15 lbs give 1/2 tablet. For dogs 16-30 lbs give 1 tablet. For dogs 31-45 lbs give 1 nad 1/2 tablet. For dogs 46-60 lbs give 2 tablets. For dogs 61-75 lbs give 2 and 1/2 tablets. For dogs 76-90 lbs give 3 tablets. For dogs 91-105 lbs give 3 and 1/2 tablets, and for dogs over 105 lbs give 4 tablets. The tablets should be given on an empty stomach at least one hour before a meal for optimal absorption. For owners who find it difficult to administer tablet(s) to their pets, Denamarin may be disguised in a small bite of food. The number of tablets administered may be gradually reduced, or increased, at any time at the recommendation of your veterinarian. Yes, dexamethasone can interact with various medications, including nonsteroidal anti-inflammatory drugs (NSAIDs), certain antibiotics, and diabetes medications. Always inform your vet about any other drugs or supplements your dog is taking. 6. How should dexamethasone be stored?

Yes, some dogs may experience gastrointestinal discomfort, including ulcers or gastritis, especially with higher doses or prolonged use. If your dog shows signs of digestive upset, like vomiting or diarrhea, consult your vet. 23. Is there a risk of liver damage with long-term dexamethasone use? Dexamethasone can be a lifeline for dogs with certain health conditions. However, its potent nature requires careful dosage and monitoring. Always consult with a veterinarian for the best course of action.Support Your Dog's Liver Health: The liver is one of the most vital organs in your pet and is responsible for removing toxins, storing energy, aiding digestion, and supporting the immune system administering tablets to their pets, Denamarin tablet(s) may be disguised in a small bite of food. Studies have shown that, in many cases, tablets or capsules given as a "dry swallow" do not pass into the stomach Signs of overdose may include excessive thirst, increased urination, extreme hunger, and potential behavioral changes. In severe cases, it can lead to more serious symptoms. If you suspect an overdose, seek veterinary attention immediately. 12. Can dexamethasone be used in pregnant or nursing dogs? There are no known drug interactions or contraindications to the use of silybin/silymarin in animals. 33,34 While mild side effects, such as gastrointestinal upset, itching and headache, have been rarely reported in primates, 33,35,36 no side effects have been noted in dogs or cats. 13,16,33,34,37,38 The specific silybin-phosphatidylcholine complex in Denamarin has been evaluated in both acute and chronic use safety studies: an acute toxicity study in dogs using levels greater than 80x the amount in Denamarin revealed no adverse physiologic effects, 38 and a chronic toxicity study in monkeys who received greater than 80x the amount in Denamarin for 26 weeks showed no compound-related adverse effects. 35 Administration As A Nutritional Supplement

The ingredients in Denamarin ® possess exceptionally wide margins of safety. Oral acute toxicity studies in rats indicated an LD 50 greater than 4,650 mg/kg for S-Adenosylmethionine. 2 Clinically healthy dogs administered 20 mg/kg/day of S-Adenosylmethionine for 6 weeks and clinically healthy cats administered S-Adenosylmethionine at 2 times the recommended daily amount for 113 days remained healthy with no adverse effects from the administration. 1,3 Denamarin ® Advanced tablets should be given on an empty stomach, at least one hour before a meal for optimal absorption. For cats, it is suggested that tablets should be followed immediately with a small amount of water to make sure the tablet passes all the way into the stomach. If pilling the dog or cat is not possible, the tablet may be administered with a small amount of food. Liver Support for Dogs: Denamarin is the #1 veterinarian recommended liver support supplement for dogs. This supplement contains s-adenosylmethionine (SAMe) to help increase levels of the antioxidant glutathione - one of the liver's main detoxifying agentsImportant: The exact dosage and duration of treatment should be determined by a vet. Potential Side Effects

morning and evening for ease of administration. For example, a daily administration of three tablets could be divided into two tablets in the morning and one tablet in the evening. Tip: Always follow your vet’s instructions on how to give this medication. When to Avoid Dexamethasone The number of tablets can be gradually reduced or increased at any time depending on the pet's needs. Denamarin coated tablets containing SAMe (s-adenosylmethionine) and silybin can be used in dogs of all sizes to help support healthy liver functions. In addition, research has shown the administration of Denamarin coated tablets to be safe for dogs. Denamarin Liver Health Supplements are brought to you by Nutramax Laboratories Veterinary Sciences, the #1 veterinarian recommended supplement company. *Source: Survey conducted among small animal veterinarians who recommended animal supplements. Key Benefits: Tablets should be given orally on an empty stomach for optimal absorption. They may be given at least two hours after a meal or one hour before a meal. The number of tablets administered may be gradually reduced, or increased, at any time at the recommendation of your veterinarian.

Benefits:

Results from a clinical trial indicate that Denamarin acts as a hepatoprotectant in dogs undergoing chemotherapy with lomustine (CCNU). 30 Pharmacokinetics Denamarin provides multi-faceted high level nutritional support for the liver due to its synergistic combination of S-adenosylmethionine (SAMe) and silybin. Because the tablet must be kept intact to prevent destruction by moisture, administration range is based on the nearest whole-tablet. The chart below is provided as a guide for administration.