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Gupta RS, Patel S, Saini N, Chen S. Robust demarcation of 17 distinct Bacillus species clades, proposed as novel Bacillaceae genera, by phylogenomics and comparative genomic analyses: description of Robertmurraya kyonggiensis sp. nov. and proposal for an emended genus Bacillus limiting it only to the members of the Subtilis and Cereus clades of species. Int J Syst Evol Microbiol. 2020;70(11):5753-5798. View abstract. Thirty six newly diagnosed diarrhea predominant IBS patients were enrolled in three clinical centres. Along with standard care of treatment, 18 patients in group one received placebo while in group two 18 patients received B. coagulans MTCC 5856 tablet containing 2 × 10 9 cfu/day as active for 90 days. Clinical symptoms of IBS were considered as primary end point measures and were evaluated through questionnaires. The visual analog scale (VAS) was used for abdominal pain. Physician’s global assessment and IBS quality of life were considered as secondary efficacy measures and were monitored through questionnaires. Results De Vecchi E, Drago L. Lactobacillus sporogenes or Bacillus coagulans: misidentification or mislabeling? Int J Probiotics Prebiotics 2006;1(1):3-10.
We look at your microbiome and we look at what’s there, what’s not there. And I do this now. I say, “Oh, you don’t have enough of this or that, so I’m going to fix this or that.” So I do that, but we’re going to be more sophisticated about it and be able to make custom probiotics for people. Myeloperoxidase (MPO) among other cellular enzymes is responsible for the production of free radicals which leads to the cellular oxidative stress ( 43). Oxidative stress is linked with the variety of human conditions such as rheumatoid arthritis, Alzheimer’s disease, Parkinson’s disease, cancers, cardiovascular diseases, depression and other neurodegenerative disease ( 43, 44). MPO has also been studied in various clinical trials as an inflammatory biomarker and used to diagnose the IBD and pro-oxidative processes in patients with depression ( 44, 45). By considering the clinical importance of MPO and its clinical relation with IBS and depression, we investigated the serum level of MPO in this study. In this study, myeloperoxidase demonstrated a significant decrease in B. coagulans MTCC 5856 (2 × 10 9 spores) receiving patients from the baseline to the end of study (day 90) unlike the placebo group. This further validates the clinical efficacy of B. coagulans MTCC 5856 in patients experiencing major depression symptoms with IBS.
Carabotti, M., Scirocco, A., Maselli, M. A., & Severi, C. (2015). The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems. Annals of Gastroenterology, 28(2), 203-209. https://www.ncbi.nlm.nih.gov/pmc/art Sabinsa’s shelf-stable LactoSpore ® probiotic has been extensively researched in the 20 years since it was introduced, and recently several new studies, including clinical studies, have been published. Areas researched include safety and tolerability, shelf life stability, genetic and phenotypic stability, and anti-diarrheal activity, all with positive and significant results. Following the fermentation, the culture is centrifuged to separate the biomass from the medium. The biomass of bacterial spores is filtered through a sterile stainless steel 100 mesh filter, and then spray-dried at high temperatures (up to 115 °C) for 2 hours. The resulting powder is combined with food grade maltodextrin to obtain commercial formulations of three different concentrations of B.coagulansMTCC 5856 spores (LactoSpore® 6 billion CFU/g, LactoSpore® 15 billion CFU/g, and LactoSpore® 100 billion CFU/g). What makes LactoSpore® extra special is that it can resist warmer temperatures. This means you can store them at room temperature, and drink a warm drink soon after taking them (which isn’t the case with most probiotics).
A5: Yes, it is advisable to consult with a healthcare professional before making changes to your routine or starting any dietary supplement, including Lactospore. A healthcare professional can provide proper guidance and ensure that the supplement is appropriate for your health needs and circumstances. References: Laboratory parameters, anthropometric and vital signs were within the normal clinical range during the 90 days of supplementation in placebo and LactoSpore ® groups. There was a significant decrease in the clinical symptoms like bloating, vomiting, diarrhea, abdominal pain and stool frequency in the patient group receiving LactoSpore ® when compared to placebo group (p < 0.01). Similarly, disease severity also decreased and the quality of life increased in the patient group compared to placebo group.Gill H, Prasad J. Bioactive components of milk: probiotics, immunomodulation, and health benefits. In: Bosze Z, editor. Advances in experimental medicine and biology. New York: Springer; 2008. p. 423–64. If modern foods contained all the goodness they once did, and if we lived like humans naturally once did, we wouldn’t need probiotics. But the thing is, we don’t. Why LactoSpore® ?
Is so key. So Mark, when it comes to shopping for probiotics, what are some of the things that people can be looking for when choosing the right probiotic?
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Absolutely. And there’s different bacteria for different things. For example for babies, often there’s a particular bacteria called Bifidobacterium infantis that’s really important for immune development, and it’s absent in most babies because the mothers have had an antibiotic some time in their life and wiped that out, or they’re born by C-section. And the 25% of calories that’s in breast milk that’s not digestible by babies is there to feed this particular bacteria and others called bifidobacterium infantis. And if you have low levels, it’s a big problem. So you can actually give the baby probiotics when they’re born in the first 100 days to help them colonize with bifidobacterium infantis and avoid the autoimmunity, the allergy, the eczema, and all these other downstream things that are going to happen if you don’t have this important bacteria. So that’s just another example of how different strains do different things. Lactospore has been shown to improve gut barrier function by increasing the production of tight junction proteins, which help maintain the integrity of the intestinal lining. This reduces the risk of toxins and pathogens entering the bloodstream and supports overall gut health (3). C. Anti-Inflammatory Properties Probiotics for antibiotic-associated diarrhea. Pharmacist's Letter / Prescriber's Letter 2000;16(1):160103.
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