2nd Edition, The Nemechek Protocol for Autism and Developmental Disorders: A How-To Guide For Restoring Neurological Function

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So if you decide to try the Nemechek protocol for SIBO or any of the other conditions it can help, plan to be on it for the long haul – at least several months. I personally will do it faithfully for 6 months before deciding one way or the other. The Nemechek Protocol itself is an approach that aims to rehabilitate the brain by targeting Autonomic dysfunction. By strengthening the immune system, it works to support the body's ability to control inflammation. The protocol is made up of four different components: As good news, constipation is a thing of the past! I can tell this protocol has been great for keeping things moving, which goes a long way to avoiding the toxin buildup that I struggled with before. This bacterial overgrowth damages the intestinal wall, releasing a substance called lipopolysaccharide (LPS) into our tissue. When our white blood cells notice the LPS, they react by releasing highly inflammatory cytokines into the blood.

I am not a fan, however, of its claim that it can “reverse autism.” Its recommendations do not appear to stem from evidence-based science, relying on what seem to be anecdotes to make its case. I’m all for giving our kiddos supplements, but you don’t need to buy a book to do that. This variant results in increased transcription and production of TNFa. This SNP is in the major histocompatibility complex and has been associated with autoimmune diseases such as celiac disease [ 52].

It’s funny. I remember reading testimonials from others who were 6 months to a year into it and thinking: Right now, I’m enjoying feeling well. A few weeks ago, the Lord really helped me during a Sunday morning service, and I’m praising Him for what appears to be a “break” from all this. It’s all just been a little (ok, a lot!) overwhelming. I went from being what I thought was “healthy” to being diagnosed with 7 chronic conditions within a year following my Lyme disease diagnosis. I completely understand your frustration! Parents around the world have been using this protocol with great success for their autistic children. Rather than working directly to increase levels of SHANK3 protein or affect stability, oxytocin is one such molecule that appears to work on downstream pathways such as long-term potentiation [ 35]. Increasing long-term potentiation (LTP) in multiple areas of the brain, including the hippocampus, has been shown to stimulate dendrite maturation and connectivity [ 36]. Decreased dendrite maturation is one of the possible downstream issues in individuals with SHANK3 deficiencies [ 9]. Due to its effects on LTP and its differential expression in the brain, oxytocin was also shown to decrease LTP-mediated pain hypersensitivity, often seen in individuals with ASD [ 36, 37].

PEMT is necessary for the conversion of phosphatidylethanolamine to phosphatidylcholine, which is the precursor to choline. Choline is needed to make acetylcholine and phospholipid membranes through its activity as a methyl donor. Dr Nemechek’s approach frequently triggers rapid and breath-taking improvements in children within a few weeks. It aims to strengthen the immune system and support the body’s ability to control inflammation. Shank3 is a scaffolding protein that is densely associated with postsynaptic glutamatergic synapses and is an important part of the postsynaptic density (PSD), a specialized protein-dense structure attached to the postsynaptic membrane. It acts as a master organizer of the PSD because of its ability to interact with multiple key synaptic components, including glutamate receptor complexes, anchoring proteins, and the actin cytoskeleton [ 7]. SHANK3 is a critical orchestrator of frontocortical function. Disrupted connectivity of the prefrontal areas may underpin the socio-communicative impairments observed in SHANK3 mutation carriers [ 8]. This variant, located in the promoter region, is suggested to alter oxytocin signaling. Lower oxytocin signaling has been associated with decreased pair-bonding and social skill scores. This variant has also been associated with impaired social cognition, as can be seen in ASD [ 58].

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Around Day 5 of taking the antibiotics for SIBO, I noticed a significant decrease in bloating. Now, I’m about 3 weeks post-Rifaximin, and I have little to no bloating anymore. On his online community he tells parents to stop giving their children the medication they've been prescribed and take his protocol instead, even though he does not know the person's medical state or medical history. So what he is saying is that you can add to your diet, Extra Virgin Olive Oil, Omega 3 and Prebiotic - all of these things are natural. EVOO is medically proven to lower inflammation and good for general health, Omega 3 is proven for brain health and is naturally occuring in salmon - i do not like fish but I take Omega 3 to help my brain and prebiotics which is made from chicory. He is not asking you to take any of these things over the normal RDA. While the field of genomically targeted personalized medicine is still in its infancy, the implications for specifying recommendations for nutrients, supplements, lifestyle, and even medications down to the individual level have the potential to change how medicine is practiced and improve patient outcomes.