The Clot Thickens: The enduring mystery of heart disease

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He talks truth to power, and challenges his colleagues to no longer cower under Public Health England, which is sustaining the Faustian pact that medicine has with big Pharma. your CO2/O2 balance is compromised. Seriously, anyone who claims otherwise is a sandwich short of a picnic. Doubling the dead space HAS to cause this issue. There was a very corny film called Kingsman a few years ago. It, too, has many parallels to our current predicament. Worth ensuring the mindless violence to see the story pan out. The highest quintile of total red meat intake was associated with an 8% higher risk for stroke, but this was driven mainly by processed red meat (which was associated with a 12% higher risk for stroke). These findings are “generally consistent with cohort studies showing that processed meat, as with most highly processed foods for that matter, are associated with an increased risk of cardiovascular events,” Mente noted. I admit I had somehow not realised that the significance of lp(a), is that it is so similar to LDL that it can be mistaken for LDL in analyses of plaques, but it performs a totally different function – being part of the clotting process no less.

The Clot Thickens | Dr. Malcolm Kendrick

However, large-cohort studies (at least, as large as can be obtained in London and NYC for this rare genetic condition) of many hundreds of HNF-type monogenic diabetics have been performed over four decades and more now. And to varying degrees, these diabetes lose beta-cell function over time. They are ALL on sulfonylureas. They only get 20% of the dose of T2Ds — they get similar efficacy from one fifth of the dose.Consider that whatever you were doing (as a lifestyle) before and whatever you did since your stents has not changed, maybe? I will keep applying your principles, as there are lots of people out there who don’t want to take statins, and are perfectly happy with their levels. Also, PCSK9 inhibitors are discussed, citing a reduction of MI of 27% vs placebo – with minimal reduction of death. OK, that is the beta cell, which is unusually susceptible to overstress and apoptosis via excessive OxPhos using glycolytic pathways and substrate (i.e. pyruvate). His statement is wholly false," was our hero’s reply. "It was his miserable villainy that deprived me of my liberty, and kept me away from my work."

The clot thickens: How to use viscoelastic testing in The clot thickens: How to use viscoelastic testing in

Malcolm the author (who's quite funny btw), does the detective work for us. Yes, the science gets a bit heavy, but overall it's really interesting. As with other modern tissue-specific degenerative conditions (I don’t care for the phrase “chronic diseases”— don’t like either of the two words applied, because I reject the implicit analogy to microbe-induced pathologies and I also reject the notion that there is anything (other than the behavior/diet of the individual) intrinsically persistent/persisting in the root cause), it is the BIOLOGY (and its evolution) that is so much disrespected and ignored. For cancer, for another example, it is Tom Seyfried, Peter Pedersen and many other heterodox “outcasts” (John Pawelek just recently died, I noticed by happenstance) who have focused on the biology rather than the massive institutional interests, and have filled out the enormous efforts and theses of Warburg from nearly a century ago, essentially completing the understanding of what cancer biology is and is not. Because I would imagine that cholesterol is not that easy to crystallise, I tried to look up crystallisation of cholesterol in the lab, but all I found was references to various biological processes. That should get the old cholesterol up a tad, which will get Smaug (my diabetes nurse-dragon) hopping up and down with angst.

In fact, I am being slightly disingenuous here. I had been thinking about blood clots for many years, but in a rather uninformed and directionless way. Many moons ago, when I was a medical student at Aberdeen, I was briefly taught cardiology by Dr Elspeth Smith. In a small group tutorial, she mentioned to us fresh faced students that LDL cannot penetrate the endothelium. Bing!

The Clot Thickens - The Enduring Mystery of Heart Disease

continued funding of recommendations of the consumption of industrially-refined seed oils (canola, soy, corn, safflower, vegetable, etc.).Mucha gente está convencida que el colesterol en la sangre (especialmente del tipo LDL, el "malo" ) es la principal causa de arteriosclerosis y en consecuencia de infartos y, por otro lado, que el nivel de colesterol en la sangre está estrechamente relacionado con la ingesta de grasas saturadas. Explicación, sencilla, clara y con importantes consecuencias para nuestra alimentación: hay que tratar de consumir poca o ninguna grasa animal, sustituir la mantequilla por margarina o aceites vegetales, la leche de vaca por "leche" de almendra y desayunar cereales en lugar de huevos... y si todo esto no funciona, hay que tomar medicinas por el resto de la vida para "bajar el colesterol". After many years of neglect, the role of thrombosis (blood clots) in myocardial infarction is being reassessed. It is increasingly clear that all aspects of the haemostatic [blood clotting] system are involved: not only in the acute occlusive event, but also in all stages of atherosclerotic plaque development from the initiation of atherogenesis to the expansion and growth of large plaques.’ The governments’ professed concern for the health services is just theatre. Last year it was “clap for heroes” , now it’s “jab the selfish”. A comparison might be On Cause/Origin: From my point of view a central property of virtually all of the modern degenerative conditions is an abnormally elevated rate of apoptosis in the underlying tissue(s)/organ(s). Many of these are insulin-regulating/expressing tissues, and this is certainly true of the vascular endothelia.

The Clot Thickens - Dr Malcolm Kendrick - Columbus Publishing

As the Blaxploitation craze comes to an end, Pam fights for better roles and hobnobs with the biggest names in showbiz. She meets the love of her life, a hot young comedian named Freddie Prinze -- whose personal demons lead to heartbreak and tragedy. An interesting quote from a 2006 novel by Linda Fairstein where one of the characters was electrocuted: The Church slapped Galileo down: he was found “vehemently suspect of heresy” (that crime you could get burned for) and sentenced to house arrest for the rest of his life. Yet, if we are to accept the LDL hypothesis, we are supposed to believe that cell membranes simply step aside, or part like the red sea, to wave through a super-tanker sized molecule. The cause of endothelial DAMAGE is homocysteine. Its caused by too high protein intake, meat, and not enough folate from leafy greens, aka Vitimin B, to convert homocysteine to next step. Yes, really, just like you were always told, eat your salads.

Below, for example, is a list of factors that are closely associated with an increased risk of cardiovascular disease. It comes from the latest UK cardiovascular risk factor calculator, called Qrisk3, which you can see here https://qrisk.org/three/ If you’ve loved listening to this podcast you might enjoy the Elly Griffiths newsletter, which is where you’ll find all the latest updates on Elly’s books, exclusive content, offers and competitions. Sign up here.